Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.
Reticulol is soluble in ethanol, methanol, DMF and DMSO.
Reticulol is soluble in ethanol, methanol, DMF and DMSO.
| References | Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. Jones R. et al. Antimicrob. Agents Chemother. 2006, 50, 2583. Retapamulin. Daum R.S. et al. Nature Reviews Drug Discovery 2007, 6, 865. |