Reveromycin B is an analogue of reveromycin A formed by rearrangement of the 6:6 spiroketal to a 5:6 spiroketal. Lacking much of the biological activity of reveromycin A, reveromycin B is a useful negative control in resolving the mode of action of this class.
Reveromycin B is soluble in ethanol, methanol, DMF and DMSO.
Reveromycin B is soluble in ethanol, methanol, DMF and DMSO.
| References | Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. Takahashi H. et al. J. Antibiot. 1992, 45, 1414. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. Miyamoto Y., et al. , J. Biol. Chem., 2002, 277, 28810. |
