SKU: S131  / 
    CAS Number: 5610-40-2

    Securinine

    ฿8,480.40 - ฿29,566.80

    Securinine is a tetracyclic alkaloid isolated from the roots of Securinega suffruticosa with an unusual structure in which the piperidine ring has a skewed boat form and the diene is not coplanar. Securinine inhibits [3H]GABA binding to rat brain membranes with an IC50 of approximately 50 µM. Securinine induces toll-like receptor (TLR)-independent macrophage activation in vitro, leading to IL-8 secretion, L-selectin down-regulation, and CD11b and MHC Class II antigen up-regulation. Securinine is an active antitumor agent, inducing p73-​dependent apoptosis preferentially in p53-​deficient colon cancer cells and inhibits the cell migration​/invasion ability of DU145 prostate cancer cells.

    Molecular Formula  C13H15NO2
    References

    Buetler JA et al (1985)  Securinine alkaloids: a new class of GABA receptor antagonist. Brain Res. 330:135

    Imado S et al (1965)  Structure of securinine hydrobromide dehydrate and the molecular structure of securinine. Chem Pharm Bull. 13:643

    Lubick K et al (2007)  Securinine, a GABA-A receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists.  Biol. 2007, 82:1062

    Zhang D et al (2019)  L-​securinine inhibits cell growth and metastasis of human androgen-​independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1​/MEK​/ERK​/STAT3​/PAX2 apoptotic pathways. Biosci Rep. 39:BSR20190469