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Phomopsin A is a an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an ansa macrocycle with a tripeptide tail, terminating in a dicarboxylic acid...
Streptomycin sulfate is a freely soluble aminocyclitol glycoside antibiotic, that was co-discovered by Salman Waksman, Albert Schatz, and Elizabeth Bugie at the Rutgers University in 1943 and was...
Piperafizine A is a methylated diketopiperazine formed by the condensation of phenylalanine, produced by a number of species in the Streptomyces genus. Piperafizine A exhibits little activity in...
Luteoreticulin is a rare nitrophenyl pyranone closely related to aureothin, neoaureothin and its unusual photoisomers SNF4435C and SNF4435D. Metabolites within this class are potent antitumor agents...
Quadrone is an unusual sesquiterpene metabolite isolated from Aspergillus terreus and first reported in 1978. Quadrone exhibits antitumor activity but has not been extensively investigated.Quadrone...
Norfloxacin is a first-generation synthetic fluoroquinolone antibiotic. Mechanism of Action Norfloxacin indirectly inhibits DNA gyrase by binding to nearby DNA substrate. DNA gyrase is an...
Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Analogues of rebeccamycin have been...
Miconazole is an imidazole antimycotic compound patented in 1968 by Janssen Pharmaceutica. It inhibits ergosterol synthesis, and a variety of cytochrome P450 enzymes. It can act as a...
7-Oxostaurosporine is the oxidised and highly fluorescent analogue of UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by...
Quinolactacin A1 is the dominant analogue of a family of quinolone metabolites produced by Penicillium citrinum. Quinolactacin A1 rapidly epimerises to equilibrate with its diastereomer quinolactacin...
Stachybotrylactam is an unusual spirodihydrobenzofuranlactam mycotoxin isolated from a Stachybotrys sp. that has immunosuppressant and weak HIV protease activity. Members of this structural class...
Mitomycin C is a bacteriocidal methylazirinopyrroloindoledione antineoplastic antibiotic isolated from Streptomyces spp. Mitomycin C can be used as an inhibitor for cell-free protein biosynthesis...