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Monascinol is a yellow-orange pigment isolated from the fungus Monascus purpureus used to produce red yeast ric . Monascinol increases the efficacy of irradiation in PC-3 prostate cancer cells, enhancing DNA damage and endoplasmic reticulum stress...
The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine A is a trihydroxylated drimane lactone which was inactive in assays for antibiotic, cytotoxic,...
Monascin (monascoflavin) is a yellow-orange pigment isolated from the fungus, Monascus purpureus used to produce red yeast rice. The structure of monascin was elucidated in 1960. Monascin has a broad bioprofile, including anti-inflammatory, antioxidant,...
Mensarcarcin is an unusual anthracene metabolite of Streptomyces sp. containing nine stereogenic centres and two epoxy functionalities first isolated by Zeeck and co-workers in the late 1990s. Mensacarcin has broad antitumor activity...
Stephacidin B, the dimer of avrainillamide, is green pigment isolated from Aspergillus ochraceus and other Aspergillus sp. Stephacidin B is more potent and selective than its monomeric analog, stephacidin A. Stephacidin B is rapidly converted to...
Ethyl mycophenolate is the ethyl ester of mycophenolic acid produced by Penicillium brevicompactum but devoid of the antifungal activity of mycophenolic acid. There are few reports of the biological activity of ethyl mycophenolate, however its analogue...
Epirubicin is the 4'-epi-isomer of the antitumor agent, doxorubicin. Epirubicin acts by inhibiting topoisomerase II resulting in DNA double strand breaks. The anthracyclines also act by evicing histone from open chromatin, deregulating the...
Cryptopleurine is a phenanthroquinolizidine secondary metabolite from Cryptocarya pleurosperma first reported by de la Lande, Melbourne University, Australia in 1948 and its structure revised in 1954. Cryptopleurine has antifungal activity via inhibition...
Molecular Formula C5H8N2O2
Aspergillin PZ is an isoindole metabolite isolated from Aspergillus awarori by activity-guided fractionation and purification. Aspergillin PZ adversely affects the hyphae and spores of P. oryzae, a nitrogen-fixing bacterium. Aspergillin PZ has weak...
Artemisinin is a sesquiterpene lactone isolated from the aerial parts of Artemisia annua L.. Artemisin is best known for its activity against the malaria parasite including resistant strains, but also has antitumor, immunomodulatory and...
Ansamitocins, a new group of ansamycin antibiotics with potent antitumor activity, were first reported in the journal Nature in 1977 by researchers from Takeda Chemical Industries. Anisomitocin P3 is the 3-O-methylpropanoyl derivative of maytansinol...
