Antitumor

Collismycin

Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2'-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was...

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Isoapoptolidin

Isoapoptolidin, originally isolated from a Nocardiopsis sp., is a ring-expanded isomer of apoptolidin. In water, apoptolidin and isoapoptolidin equilibrate in a ratio of ~1.5:1 within hours. In a rapid F0F1-ATPase assay, isoapoptolidin was approximately...

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Concanamycin A

Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface...

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Resistoflavine

Resistoflavine is a rare, boat-shaped, pentacyclic polyketide isolated from several species of Streptomyces, often co-produced with resistomycin. Resistoflavine exhibits weak antibacterial activity against Gram positive and Gram negative bacteria and...

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Actinotetraose hexatiglate

Actinotetraose is a unique tetrasaccharide with six tiglate esters isolated from an unidentified Amycolatopsis culture. The sugar possesses a two-fold axis of symmetry and is a co-metabolite of quinaldopeptin, a potent antitumor agent.Actinotetraose...

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Anguinomycin A

Anguinomycin A is a natural polyketide and analog of Leptomycin B, an inhibitor of protein nuclear export.  It is isolated from Streptomyces spp., and displays anti-cancer activity.  Anguinomycins B, C and D are also members of the Leptomycin...

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Sch 38519

Sch 38519 is an isochromanequinone, structurally related to lactoquinomycin. Sch 38519 inhibits thrombin-induced aggregation of human platelets and is active against Gram positive and Gram negative bacteria.Sch 38519 is soluble in ethanol, methanol,...

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Borrelidin

Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.Borrelidin is soluble in ethanol, methanol, DMF and...

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Dihydroaeruginoic acid

Dihydroaeruginoic acid is a simple aromatic siderophore produced by several species of Pseudomonas. Dihydroaeruginoic acid exhibits antibacterial, antifungal and antitumor activity.Dihydroaeruginoic acid is soluble in ethanol, methanol, DMF and DMSO...

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Bleomycin A5 Hydrochloride

Bleomycin A5 Hydrochloride is part of the Bleomycin complex.  It is an anti-neoplastic glycoprotein antibiotic used in cancer research.  The Bleomycins were originally isolated for their broad spectrum antibacterial activity.We also offer:...

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Norcantharidin

Norcantharidin is an antitumor drug that is a modified version of the natural product antitumor drug cantharidin. Norcantharidin is demethylated, which reduces its urinary system toxicity but not its antitumor efficacy. It has been found to induce...

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Concanamycin B

Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A.Concanamycin B is soluble in ethanol,...

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