Antitumor

Setomimycin

Setomimycin is a rare 9,9'-bianthryl antibiotic first isolated from a strain of Streptomyces pseudovenezuelae by Omura and colleagues at the Kitasato Institute, Japan, in 1978. Setomimycin is active against Gram positive bacteria, including mycobacteria,...

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Bafilomycin A1

Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumor cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type...

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Bafilomycin B1

Bafilomycin B1 is a member of a potent family of macrocyclic lactones. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential agent for treating osteoporosis...

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Bafilomycin C1

Bafilomycin C1 is a member of a potent family of macrocyclic lactones. Bafilomycin C1 is broadly active against bacteria, fungi, insects, nematodes and cestodes. Bafilomycin C1 has attracted interest as a potential agent for treating osteoporosis. The...

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Bafilomycin D

Bafilomycin D is a member of a potent family of macrocyclic lactones. Bafilomycin D contains the ring-opened side chain and is a much more stable analogue of bafilomycin A1. Limited availability has restricted a more in depth investigation of this...

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Luzopeptin A

Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents. Luzopeptin A is also a potent inhibitor of HIV-1 and HIV-2 reverse transcriptase.  Luzopeptin A is soluble in DMF or DMSO. Moderately soluble...

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Tetranactin

Tetranactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp.. Unlike the other macrotetrolides, tetranactin exhibits potent insecticidal activity.Tetranactin is soluble in ethanol, methanol, DMF and DMSO.Mechanism of...

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Thiolutin

Thiolutin is an antibiotic first described by Tanner and co-workers in 1950. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Thiolutin suppresses tumor cell-induced...

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Pyrocoll

Pyrocoll is a small secondary metabolite formed by the dimerisation of pyrrole-2-carboxylic acid and produced by many Streptomyces species. Pyrocoll is an important dereplication standard in discovery, displaying a highly distinctive UV spectrum. The...

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Gilvocarcin M

Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin M contains a methyl group in the 8-position, and is less active than the vinyl analogue (gilvocarcin V), which is thought to...

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Transplatin

Transplatin is the less-active isomer of the DNA damanging, platinum antitumor drug cisplatin, which is used in the treatment of a variety of solid tumors. However, it has been reported that the antitumor activity of transplatin can be photo-activated...

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Gilvocarcin V

Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin V contains a vinyl group in the 8-position, and is the most potent analogue of the complex. It is thought to act as an...

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