Antitumor

Antimycin A1

Antimycin A1 is the most hydrophobic of the four analogs of the Antimycin A complex. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes.Antimycin...

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Anhydroepiophiobolin A

Anhydroepiophiobolin A is a dehydrated analogue of ophiobolin epimerised at the C6 position. Anhydroepiophiobolin A is the major terminal degradation product of ophiobolin A and is co-produced with other ophiobolins in many Bipolaris species. Prior to...

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Tubercidin

Tubercidin is a nucleoside metabolite first isolated from Streptomyces tubericidus. Tubercidin, like other nucleosides, is a broad spectrum potent chemotherapeutic agent active against viruses, bacteria, fungi, protozoans and tumors. Soluble in...

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Antimycin A2

Antimycin A2 is a homologue of the antimycin complex, first resolved from antimycin A1 in 1959. Antimycin A2, like all antimycins, is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A2 exhibits broad...

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Antimycin A3

Antimycin A3 is an homolog of the Antimycin complex (syn: Antimycin A).  Antimycin A3 is one of four closely related structures in the mixture (others include Antimycin A1, A2 and A4).  First isolated in 1958 from Streptomyces blastimyceticus...

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Clarithromycin related compound D, EvoPure®

Clarithromycin related compound D, EvoPure® (3″-N-demethyl-6-O-methylerythromycin A) is a highly purified impurity found in Clarithromycin that can be used as a reference standard. We also offer: Clarithromycin, USP (C128) Clarithromycin...

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Bithionol

Bithionol is an anti-parasitic drug and has recently been found to have anti-ovarian cancer properties. In one study, bithionol inhibited all tested ovarian cancer cell lines with IC50 values from 19 µM - 60 µM.Mechanism of ActionThe mechanism of action...

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Antimycin A4

Antimycin A4 is the most polar of the major components of the antimycin complex, first isolated in 1958 from Streptomyces blastimyceticus and co-produced with antimycin A3. Antimycin A4 exhibits broad biological activity as an antifungal, anthelmintic,...

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Enniatin A

Enniatins are a family of depsipeptide ionophores, produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...

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Antimycin

Antimycin (syn: Antimycin A) is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogs in the...

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Enniatin A1

Enniatins are a family of depsipeptide ionophores produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...

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Enniatin B

Enniatins are a family of depsipeptide ionophores produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...

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