Antitumor

19,20-epoxycytochalasin C

19,20-Epoxycytochalasin C is a major component of the cytochalasin complex. Although reported in the literature, there is no available biological data on the metabolite other than in-house data suggesting the presence of the epoxide renders the...

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19,20-epoxycytochalasin D

19,20-Epoxycytochalasin D is a major component of the cytochalasin complex. Although reported in the literature, there is no available biological data on the metabolite other than in-house data suggesting the presence of the epoxide renders the...

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Nisin

Nisin (Nisin A) is a natural bacteriocin polypeptide antibiotic known as a lantibiotic. It is a 34-amino acid polycyclic antibacterial peptide.  It was isolated in the late 1930s from Lactococcus lactis.  Nisin A and Nisin Z are two...

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21-Hydroxyoligomycin A

21-Hydroxyoligomycin A is a rare member of the Oligomycin class, isolated as a co-metabolite of nemadectin, hence it was originally named Nemadectin omega. Only limited literature references are available. In-house testing suggests that...

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Fostriecin

Fostriecin is the most fully characterised member of a family of phosphate esters of a triene antibiotic. The antitumor potential of Fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent...

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Fumitremorgin C

Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. It reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.Fumitremorgin C is soluble in ethanol, methanol, DMF or...

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Oligomycin A

Oligomycin A is a dominant analog of the Oligomycin class of macrocyclic lactones isolated from selected strains of Streptomyces sp. The class includes the analogs/isomers A through G.  Different isomers are highly specific for the disruption of...

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Oligomycin B

Oligomycin B is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic cytotoxicity and...

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Oligomycin C

Oligomycin C is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic cytotoxicity...

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Oligomycin D

Oligomycin D (Rutamycin) is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic...

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Pefloxacin Mesylate Dihydrate

Pefloxacin Mesylate Dihydrate is a broad-spectrum, synthetic, third-generation fluoroquinolone antibiotic.  Pefloxacin, an analog of Norfloxacin, was discovered in 1979.  Pefloxacin, like other fluoroquinolones, inhibits bacterial DNA gyrase...

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Clotrimazole

Clotrimazole is a broad-spectrum antifungal belonging to the imidazole subclass of azole compounds. These compounds interfere with the biosynthesis of ergosterol, a major membrane component of the fungal cytoplasmic membrane. Clotrimazole was discovered...

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