Immunosuppressants

Delta-2-ivermectin B1a

Δ2-Ivermectin B1a is an irreversible base degradation product of ivermectin found in animals treated with ivermectin and in the environment. Δ2-Ivermectin B1a is formed by rearrangement of the naturally occurring Δ3-group to the 2-position. Despite the...

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Isocyclosporin A

Isocyclosporin A is a rearranged degradation product formed by acid treatment of Cyclosporin A under aqueous and non-aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying Cyclosporin A. The pharmacology...

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Neochlorogenic acid

Neochlorogenic acid is a natural polyphenol compound found primarily in fruits. Other polyphenols have proven to have a wide array of bioactivity, and already neochlorogenic acid has demonstrated anti-inflammatory activity.Mechanism of ActionResearchers...

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LL Z1640-2

LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation...

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Rifampicin

Rifampicin (syn: Rifampin) is a semisynthetic antimicrobial compound derived from rifamycin SV and originally developed by the Lepetit group in 1965.  Rifampicin shows activity against Gram-positive bacteria, particularly mycobacteria like...

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Monactin

Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore...

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Flurbiprofen

Flurbiprofen is a non-steroidal anti-inflammatory compound (NSAID).  Flurbiprofen is practically insoluble in water, and freely soluble in ether and methanol.This product is considered a dangerous good. Quantities above 1 g may be subject to...

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Indomethacin

Indomethacin is a part of the non-steroidal anti-inflammatory compound (NSAID) class, and as such exhibits anti-inflammatory, antipyretic and analgesic properties. Indomethacin has also demonstrated the ability to inhibit cell growth and induce apoptosis...

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Flumethasone

Flumethasone is a topical corticosteroid of the glucocorticoid class used in the treatment of skin disorders where it reduces inflammation.Flumethasone is insoluble in water.Molecular FormulaC22H28F2O5ReferencesAbdel-Aleem, E. A., Hegazy, M. A., Sayed, N...

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Prodigiosin

Prodigiosin is an intensely red pyrrole pigment produced by several bacteria, most notably Serratia marcescens. Prodigiosin has a broad biological profile with activity against fungi, tumor cell lines and malaria. It was shown to be an immunosuppressant...

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D-Penicillamine

D-Penicillamine is a copper chelating agent that also functions as a disease-modifying, anti-rheumatic immunosuppressant, and a treatment for cystinuria.TOKU-E offers both D-penicillamine (P107) and L-penicillamine (P112). While they are...

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Elaiophylin

Elaiophylin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase and is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelmintic and...

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