Antimicrobials

Oseltamivir Phosphate

Oseltamivir Phosphate is an inhibitor of influenza viral neuraminidase.  It is also an antiviral used against influenza A and B.  Oseltamivir was discovered at Gilead in 1997 using shikimic acid as a starting point for synthesis.  The...

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Posaconazole

Posaconazole is a synthetic, broad-spectrum, second generation triazole with antifungal activity. It has potent in vitro and in vivo trypanocidal activity. It was discovered by Schering-Plough and it is a structural analog of itraconazole.  It has...

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Gageostatin A

Gageostatin A is an antimicrobial peptide (AMP) isolated from a marine strain of Bacillus subtilis. Gageostatin A is a linear lipopeptide composed of 7 peptides, and has shown initial bioactivity against pathogenic fungi, Gram-positive and Gram-negative...

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TAN 420E

TAN 420E is the hydroquinone analogue of herbimycin A. TAN 420E has been patented as an antibacterial, antifungal and antiprotozoan active. The study of TAN 402E has been over-shadowed by the more readily accessible quinone. Little is known of the...

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Actagardin

Actagardin is a high molecular weight tetracyclic antibiotic produced by several species of Actinoplanes. Actagardin is an antibiotic in which the macrocyclic rings are formed by thioether, rather than disulphide, bridges. Actagardin is a potent Gram...

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Isoxanthohumol

Isoxanthohumol is one of many bioactive prenylflavonoids that can be isolated from the hops plant, or Humulus lupulus L. While the primary research interest is in its apparent chemotherapeutic prevention activity, isoxanthohumol has also shown notable...

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Bischloroanthrabenzoxocinone

Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 µg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities...

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A 39183A

A 39183A is factor A from the A-39183 antibiotic complex. The A-39183 antibiotic complex was isolated from the aerobic fermentation of Streptomyces (strain NRRL 12049) by Eli Lilly in 1979.  This complex contains closely-related factors A, B, C, D,...

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A 54556A

A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. ADEPs are...

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Ceftazidime Hydrochloride

Ceftazidime Hydrochloride is a non-toxic hydrochloride salt derivative of Ceftazidime, a broad-spectrum, third-generation, β-lactam cephalosporin that interferes with bacterial cell wall synthesis.  Patented in 1979 by Glaxo Group, it came into...

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Citrinin

Citrinin is a quinonemethine mycotoxin produced by diverse fungi including Aspergillus and Penicillium. Citrinin has been extensively investigated and is a potent nephrotoxin with hepatoxic and teratogenic activity. Citrinin is the causative agent of...

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Corynecin I

Corynecin I is a member of a naturally-occurring complex of chloramphenicol-like acyl nitrophenylpropylamines isolated from Corynebacterium hydrocarboclastus in 1972. Corynecin I is active against Gram positive and Gram negative bacteria. Although less...

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