Aureothin, an unusual pyranone metabolite, has broad biological actions including antitumor, antimicrobial and insecticidal activities. More recently, aureothin has been shown to be a potent...
1,6-Dimethoxyphenazine is a simple phenazine produced by several species of Streptomyces. Dimethoxyphenazine is a weakly active antibacterial metabolite with activity against mycobacteria...
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases...
Cinnamycin (syn: lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium cinnamoneus, first isolated in 1952. Cinnamycin belongs to the class...
Desertomycin A is a 42-membered macrocyclic lactone with broad spectrum activity against Gram positive and Gram negative bacteria, yeasts and fungi. There has been little investigation into the mode...
Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower...
Emodin is a tyrosine kinase inhibitor and is a natural anthraquinone derivative found in the roots and rhizomes of multiple plants. It has anti-inflammatory, antiviral, antibacterial and anticancer...
Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl...
10'-Desmethoxystreptonigrin is a close analogue of streptonigrin produced by selected Streptomyces species. It is a moderately potent inhibitor of farnesylation of RAS P21 protein, 3-fold more active...
Mithramycin A was the first of the aureolic acid class of antitumor antibiotics, isolated from Streptomyces.Mithramycin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility...
Demeclocycline, a chlortetracycline analog produced by a mutagenised strain of Streptomyces aureofaciens, was first isolated in 1957. Like all tetracyclines, Demeclocycline shows broad-spectrum...
Meleagrin is an alkaloid with antitumor and antibiotic activity, isolated from a number of species of Penicillium. Meleagrin is a common taxonomic marker for fungal contamination of foodstuffs. Note...
