Antibacterials

Avrainvillamide

Avrainvillamide is the monomer of the stephacidin B dimer. Avrainvillamide is active against the proto-oncogene, mutated NPM1, commonly present in patients with acute myeloid lukemia. Avrainvillamide alkylates Cys275 of mutated NPM1, inhibits...

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Avilamycin C

Avilamycin C is a chlorine-containing polysaccharide antibiotic produced by Streptomyces viridochromogenes. Avilamycin is active against Gram-positive bacteria and is used as a growth promotant and for prevention of necrotic enteritis in animals...

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Avilamycin A

Avilamycin A is a chlorine-containing polysaccharide antibiotic produced by Streptomyces viridochromogenes. Avilamycin is active against Gram-positive bacteria and is used as a growth promotant and for prevention of necrotic enteritis in animals...

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Atranorin

Atranorin is a common lichen metabolite that is allergenic and has a broad biological profile, with Anti-inflammatory, analgesic, wound healing, antifungal, antibacterial, antioxidant, antiviral and immunomodulatory. Atranorin has cytotoxic,...

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Aspyrone

Aspyrone is a chiral dihydropyranone with nematocidal activity isolated from Aspergillus melleus by researchers at ICI in 1967. Aspyrone has antifungal and antibacterial activity and is more active than its derivatives or asperlactone. The epoxy group...

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Aspergillin PZ

Aspergillin PZ is an isoindole metabolite isolated from Aspergillus awarori by activity-guided fractionation and purification. Aspergillin PZ adversely affects the hyphae and spores of P. oryzae, a nitrogen-fixing bacterium. Aspergillin PZ has weak...

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Ascochin

Ascochin is isolated from the endophytic fungus, Ascochyta species with antifungal, antibacterial and phytotoxic properties. Molecular Formula  C12H10O5 References Krohn K et al (2007)  Bioactive natural products from the endophytic...

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Artemisin

Artemisinin is a sesquiterpene lactone isolated from the aerial parts of Artemisia annua L.. Artemisin is best known for its activity against the malaria parasite including resistant strains, but also has antitumor, immunomodulatory and...

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Aranciamycin A

Aranciamycin A is an anthracycline bearing a methyl-L-rhamnose sugar in the 2-O position. Aranciamycin A has antitumor and Gram positive antibiotic activity and is a potent inhibitor of Clostridium histolyticum collagenase, with an IC50 = 3.7 x 10-​7M...

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Aquastatin A

Aquastatin A, produced by Fusarium sp., is an inhibitor of mammalian adenosine triphosphatases with an IC50 of 7.1 µM against Na+/K+-ATPase 6.2 µM against H+/K+-ATPase. Aquastatin A is a potent inhibitor of enoyl-ACP reductase (FabI) of...

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Apramycin

Apramycin is a structurally unique broad-spectrum aminoglycoside with a bicyclic sugar moiety and a monosubstituted deoxystreptamineactive. Apramycin inhibits the translocation step of bacterial protein synthesis and induces translation errors. Apramycin...

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Ansamitocin P3

Ansamitocins, a new group of ansamycin antibiotics with potent antitumor activity, were first reported in the journal Nature in 1977 by researchers from Takeda Chemical Industries. Anisomitocin P3 is the 3-O-methylpropanoyl derivative of maytansinol...

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