SKU: S082  / 
    CAS Number: 22733-60-4

    Siccanin

    Mex$8,903.11 - Mex$31,161.87

    Siccanin is an unusual fused phenolic pentacycle first isolated from Helminthosporium siccans reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the Siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by Siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.

    Siccanin is soluble in ethanol, methanol, DMF and DMSO.

    Mechanism of Action Siccanin inhibits succinate dehydrogenase in the terminal electron transport system.
    References Ishibashi KJ (1962)  Studies on antibiotics from Helminthosporium sp. fungi. VII. Siccanin, a new antifungal antibiotic produced by Helminthopsporium siccans. Antibiot. Series A 15:161

    Nose K and Endo AJ (1971)  Mode of action of the antibiotic Siccanin on intact cells and mitochondria of Trichophyton mentagrophytes. J. Bacteriol. 105:176

    Mogi TJ et al (2009)  Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor.  Biochem. 146:383