Sinefungin, a polar nucleoside antifungal active with broad biological activity, was isolated from a number of species of Streptomyces in the early 1970s. Sinefungin can be used as a bioprobe to block methyltransferase-dependent pathways.
Sinefungin is a natural nucleoside analog of S-adenosylmethionine and inhibits Streptococcus pneumoniae biofilm growth. Its derivatives can be used as inhibitors and structure probes for human protein lysine methyltransferase SETD2.
Sinefungin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Sinefungin acts by inhibiting a wide range of methyltransferases, including the methylation of bases in DNA and RNA which alters cytosine deamination and gene expression. |
| Molecular Formula | C15H23N7O5 |
| Microbiology Applications | Sinefungin has activity against the dengue and Zika viruses with IC50 values of 0.63a nd 1.18 uM respectively. |
| References |
Bangaru S, Saravanan M, Manickam S, Manivannan P, Perumalsamy R (2022) Exploring the structure, binding mode, flexibility and toxicity nature for Sinefungin molecule: A theoretical approach. Res. Chem. Intermed. 48:2745-2764 Kuroda Y, Yamagata H and Nemoto M et al (2019) Antiviral effect of Sinefungin on in vitro growth of feline herpesvirus type 1. J. Antibiot. 72:981-985 Mahalapbutrr P, Kongtaworn N, Thanyada Rungrotmongkol T (2020) Structural insight into the recognition of S-adenosyl-L-homocysteine and sinefungin in SARS-CoV-2 Nsp16/Nsp10 RNA cap 2′-O-Methyltransferase. Comput. Struc. Biotechnol. J. 18:2757-2765
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