SKU: S004  / 
    CAS Number: 53179-09-2

    Sisomicin Sulfate

    $2,416.00 - $4,216.00
    Sisomicin Sulfate

    Sisomicin Sulfate is a soluble broad-spectrum aminoglycoside antibiotic, and a dihydro analog of Gentamicin C1a Sulfate, Evopure.  Sisomicin was first isolated in 1970 from Micromonopora inyoensis btained from soil samples collected in the Inyo National Forest in California.

    Sisomicin Sulfate is a bacterial protein synthesis inhibitor that binds to the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibiting translocation.  It is effective against most strains of Klebsiellk spp., Escherichia coli, Pseudomonas aeruginosa, Enterobacter and Proteus spp.. It is potentially active for conjunctiva. Sisomicin has been used in disk and tube dilution sensitivity testing methods.

    Sisomicin Sulfate is generally more potent than Gentamicin, and has shown antibacterial synergy with beta-lactam antibiotics against a large range of bacteria.

    Sisomycin Sulfate is soluble in water.

    Mechanism of Action Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
    Spectrum Sisomicin is a broad-spectrum antibiotic which targets a wide range of Gram-positive and Gram-negative bacteria.
    Microbiology Applications

    Sisomicin Sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.

    Representative MIC values include:

    • Haemophilus influenzae 1.6 µg/mL – 3.1 µg/mL
    • Pseudomonas aeruginosa 2 µg/mL
    • For a representative list of Sisomicin MIC values, click here.
    Molecular Formula C19H37N5O7 •2.5 H2SO4
    References

    Davis BD (1987)  Mechanism of bactericidal action of aminoglycosides.  Microbiol. Rev. 51(3):341-350

    Sanders WE and and Christine C. Sanders CC (1980)  Sisomicin: A review of eight years' experience.  Rev. Infect. Dis. 2(2):182-195

    Weinstein M, Wagman G and Waitz J (1976)  J. Infection 4(Suppl 4): S285

    Weinstein MJ et al (1970)  Antibiotic 6640, A new Micromonospora-produced aminoglycoside antibiotic.  J. Antibiotic. 23 (11):551-554 
    MIC Diplococcus pneumoniae| 3.1 － 6.3|| Haemophilus influenzae| 1.6 － 3.1|| Pseudomonas aeruginosa| 2||