spiro-Oxanthromicin was first isolated from a soil-derived Streptomyces sp. by Capon in 2014. spiro-Oxanthromicin inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells (IC50 27 µM) and is highly synergistic with its co-metabolites including (±)-oxanthromicin in this assay. spiro-Oxanthromicin inhibits Bacillus cereus (MIC 12.5 µg/mL) but was inactive against HSV-1, Mycobacterium tuberculosis H37Ra and phytopathogenic fungi. spiro-Oxanthromicin shows minimal cytotoxicity.
| Molecular Formula | C36H26O10 |
| References |
Bunbamrunga N et al (2018) Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066. Phytochem. Lett. 25:109 Salim A et al (2014) Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Org. Biomol. Chem. 12:4872 |
