SKU: S133  / 
    CAS Number: 1616622-10-6

    spiro-Oxanthromicin A

    $148.00 - $516.00

    spiro-Oxanthromicin was first isolated from a soil-derived Streptomyces sp. by Capon in 2014. spiro-Oxanthromicin inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells (IC50 27 µM) and is highly synergistic with its co-metabolites including (±)-oxanthromicin in this assay. spiro-Oxanthromicin inhibits Bacillus cereus (MIC 12.5 µg/mL) but was inactive against HSV-1, Mycobacterium tuberculosis H37Ra and phytopathogenic fungi. spiro-Oxanthromicin shows minimal cytotoxicity.

    Molecular Formula  C36H26O10
    References

    Bunbamrunga N et al (2018)  Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066.  Phytochem. Lett. 25:109

    Salim A et al (2014)  Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Org. Biomol. Chem. 12:4872