Stachybotrylactam is an unusual spirodihydrobenzofuranlactam mycotoxin isolated from a Stachybotrys sp. that has immunosuppressant and weak HIV protease activity. Members of this structural class show diverse activity including antiviral, endothelin and pancreatic cholesterase inhibition.
Stachybotrylactam is soluble in ethanol, methanol, DMF and DMSO.
| References | Total synthesis and structure revision of Stachybotrys spirolactams. Deng W.P. et al. J. Org. Chem. 2003, 68, 7422. Novel spirodihydrobenzofuranlactams as antagonists of endothelin and as inhibitors of HIV-1 protease produced by Stachybotrys sp. I. Fermentation, isolation and biological activity. Roggo B.E. et al. J. Antibiot. 1996, 49, 13. Stachybotrys toxins I, Jarvis B.B. et al. Nat. Toxins 1995, 3, 10. |