Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumor active, inducing apoptosis in a variety of cell lines. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.
Staurosporine is soluble in ethanol, methanol, DMF and DMSO.
Staurosporine is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. |
| Molecular Formula | C28H26N4O3 |
| References | IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin. Peet G.W. et al. J. Biol. Chem. 1999, 274, 32655. Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines. Boix J. et al. Neuropharmacology 1997, 36, 811. Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Ruegg U.T. et al. Trends Pharmacol. Sci. 1989, 10, 218. |