Streptidine, EvoPure® (dihydrosteptomycin impurity A) is a metabolite derived from streptomycin via acid hydrolysis and has been found to be a leading cause of ototoxicity caused by streptomycin in rat models. The compound has demonstrated physiological properties and has been shown to have antimicrobial activity.
EvoPure products are purified single antibiotic fractions, most are >99% pure.
For additional EvoPure products, click here.
| Molecular Formula | C8H18N6O4 |
| Spectrum | Streptidine has a broad-spectrum of activity against Gram-positive and Gram-negative bacteria. |
| Mechanism of Action |
Aminoglycosides bind to the 16S rRNA of the 30S ribosomal subunit interfering with the binding of the formyl-methionyl-tRNA to the 30S subunit. This leads to the misreading of codons, protein synthesis inhibition, and eventually the death of the bacterial cells. |
| References |
Granados, O (2005) Streptidine, a metabolic derivative produced after administration of streptomycin in vivo, is vestibulotoxic in rats. Histol. and Histopathol 20(2):357-364 PMID 15736038 |
