SKU: S135  / 
    CAS Number: 57-92-1


    $50.00 - $175.00

    Streptomycin, a metabolite of Streptomyces griseus, was first published as an antibiotic active against Gram positive and Gram negative organisms by Schatz, Bugle and Waksman in 1944. Streptomycin was the first aminoglycoside antibiotic and first agent effective for tuberculosis. Streptomycin binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome irreversibly, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit.

    Molecular Formula  C21H39N7O12

    Luzzatto L et al (1968)  Mechanism of action of Streptomycin in E. coli: Interruption of the ribosome cycle at the initiation of protein synthesis. Proc. Nat. Acad. Sci.60:873

    Schatz A et al (1944)  Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. Proc. Soc. Exp. Biol. Med. 66:60