SKU: S037  / 
    CAS Number: 23282-55-5

    Sulfachloropyridazine Sodium

    $94.50 - $393.75

    Sulfachloropyridazine Sodium is the sodium salt of Sulfachloropyridazine, a sulfonamide antibiotic. It has been used to treat the bacteria causing urinary tract infections. It is commonly used in aquaculture and animal husbandry. Sulfachloropyridazine can be used to study kinetics and reaction pathways and has been used as a model for sulfonamide detection.

    Mechanism of Action

    Sulfachloropyridazine blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfachloropyridazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

    Spectrum Effective against Gram-positive and Gram-negative bacteria and Mycoplasma.
    Molecular Formula C10H8ClN4O2S ∙ Na
    Microbiology Applications

    Sulfachloropyridazine Sodium is used to study kinetics, reaction pathways and toxicity evolution

    References

    Dirany A, Sirés I, Oturan N, Ozcan A, Oturan MA (2012) Electrochemical treatment of the antibiotic sulfachloropyridazine: Kinetics,
    reaction pathways, and toxicity evolution. Environ. Sci. Technol. 46(7):4074-4082 PMID 22332959

    Hunter, WJ and Shaner DL (2011) Studies on removing sulfachloropyridazine from groundwater with microbial bioreactors. Curr. Microbiol. 62: 1560-1564 PMID 21327887

    Matusik JE, Sternal RS, Barnes CJ, Sphon JA (1990) Confirmation of identity by gas chromatography/tandem mass spectrometry of
    sulfathiazole, sulfamethazine, sulfachloropyridazine, and sulfadimethoxine from bovine or swine liver extracts after quantitation by gas
    chromatography/electron-capture detection. J. Assoc. Off. Anal. Chem. 73(4):529-533 PMID 2211474