Sulfamethoxazole related compound B, EvoPure (4-Amino-N-{4-[N-(5methlisoxazol-3-yl)sulfamoyl]phenyl}benzenesulfonamide) is an impurity found in the sulfonamide antibiotic, Sulfamethoxazole. The product can be used as a reference standard. Sulfamethoxazole related compound B can be used as an analytical reference standard.
- Sulfamethoxazole related compound A, EvoPure (S063)
| Molecular Formula | C16H16N4O5S2 |
| Plant Biology Applications | In Arabidopsis, there is considerable evidence that sulfanilamides inhibit the bifunctional folate biosynthetic enzyme hydroxymethyldiopterin pyrophosphokinase/dihydropteroate synthase (HPPK/DHPS). However, the network of plant responses to these compounds remains to be characterized. |
| References |
Henry RJ (1943) The mode of action of Sulfonamides. Bacteriol. Rev. 7(4):175-262 PMID 16350088 Schreiber KJ et al (2012) Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound Sulfamethoxazole. BMC Plant Biol. 12:226 PMID 23176361 |
| MIC | Enterobacter aerogenes| 0.03 － 32| 156| Enterobacter cloacae| 0.03 － 32| 186| Enterobacteriaceae| 4 － 128| 401| Escherichia coli| ≤0.015 － >32| 186| Escherichia coli (chicken isolate)| ? － ?| 1037| Escherichia coli (chicken isolate)| ? － ?| 1037| Escherichia coli (swine isolate)| ? － ?| 1037| Escherichia coli (swine isolate)| ? － ?| 1037| Haemophilus influenzae| 100 － >1000| 1413| Haemophilus influenzae (ESBL)| 0.06 － 16| 186| Haemophilus influenzae (non-ESBL)| 0.12 － 1| 186| Haemophilus spp.| 0.5 － 32| 401| Klebsiella pneumonia| 0.06 － >32| 186| Moraxella catarrhalis (ESBL)| 0.06 － 0.5| 186| Moraxella catarrhalis (non-ESBL)| 0.03 － 0.12| 186| Neisseria spp.| 0.25 － 8| 401| Nocardia asteroides| 1600 － >1600| 1404| Pseudomonas aeruginosa| >32 － ?| 186| Pseudomonas aeruginosa (ATCC 15692)| 128 － ?| 786| Pseudomonas aeruginosa (DB5218)| 128 － ?| 786| Pseudomonas aeruginosa (DR3062)| 128 － ?| 786| Pseudomonas aeruginosa (PA01)| 128 － ?| 786| Pseudomonas aeruginosa (PT121)| 128 － ?| 786| Streptococcus equi subsp. equi (2002–2006)| ? － ?| 937| Streptococcus equi subsp. zooepidemicus (2002–2006)| ? － ?| 937| Streptococcus equi subsp. zooepidemicus (2007–2008)| ? － ?| 937| Streptococcus pneumonia (Duke-2)| 152 － ?| 918| |
