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Detailed Description
CAS Number: 599-79-1
Molecular Formula: C18H14N4O5S
Molecular Weight: 398.39
Mechanism of Action: The mechanism of Sulfasalazine is not yet elucitated but one proposed mechaanism based on in vitro and in vivo models suggests it is via the inhibition of prostalandins that results in its anti-inflammatory properties. Like methotrexate, Sulfasalazine enhances adenosine release at an inflamed site and that adenosine diminishes inflammation via occupancy of A2 receptors on inflammatory cells. It also interferes with DNA synthesis.
Storage Conditions: 2-8C
Tariff Code: 2935.90.4200
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Specifications
Form: Powder
Appearance: Yellow to dark orange powder
Source: Synthetic
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Technical Data
Solubility: Soluble in aqueous solution of alkali hydroxides. Very slightly soluble in ethanol. Practically insoluble in water.
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References
References:
Doxsee DW (2007) Sulfasalazine‐induced cystine starvation: Potential use for prostate cancer therapy 67(2):162-171
Gadangi P et al (1996) The anti-inflammatory mechanism of Sulfasalazine is related to adenosine release at inflamed sites. J Immunol. 156(5):1937-1941 PMID 8596047
Gout P, Buckley A, Simms C and Bruchovsky N (2001) Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc − cystine transporter: A new action for an old drug. Leukemia 15: 1633–1640
Sulfasalazine is a synthetic salicylic acid derivative and sulfonamide which can act as an antirhematic and gastrointestinal agent. It is formulated as a prodrug, and is metabolized into active metabolites sulfapyridine and mesalazine (5-aminosalicylic acid; 5-ASA). Sulfasalazine and its metabolites have antibacterial, immunosuppressive, and anti-inflammatory properties. The compound is an inhibitor of cystine-glutamate.
CAS Number: 599-79-1
Molecular Formula: C18H14N4O5S
Molecular Weight: 398.39
Mechanism of Action: The mechanism of Sulfasalazine is not yet elucitated but one proposed mechaanism based on in vitro and in vivo models suggests it is via the inhibition of prostalandins that results in its anti-inflammatory properties. Like methotrexate, Sulfasalazine enhances adenosine release at an inflamed site and that adenosine diminishes inflammation via occupancy of A2 receptors on inflammatory cells. It also interferes with DNA synthesis.
Storage Conditions: 2-8C
Tariff Code: 2935.90.4200
Form: Powder
Appearance: Yellow to dark orange powder
Source: Synthetic
Solubility: Soluble in aqueous solution of alkali hydroxides. Very slightly soluble in ethanol. Practically insoluble in water.
References:
Doxsee DW (2007) Sulfasalazine‐induced cystine starvation: Potential use for prostate cancer therapy 67(2):162-171
Gadangi P et al (1996) The anti-inflammatory mechanism of Sulfasalazine is related to adenosine release at inflamed sites. J Immunol. 156(5):1937-1941 PMID 8596047
Gout P, Buckley A, Simms C and Bruchovsky N (2001) Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc − cystine transporter: A new action for an old drug. Leukemia 15: 1633–1640