Sultriecin is the dominant analogue in a family of triene antibiotics originally thought to be sulfate esters, but recently unequivocally proven to be phosphate esters. While re-naming of the compound as "phostriecin" may cause confusion with "fostriecin", it is now recognised that sultriecin is a phosphate ester of fostriecin. Sultriecin displays potent antifungal and antitumor activity.
Sultriecin is soluble in water, optimial stability in aqueous buffered solutions at pH 6.5. NOTE: hydrolysis of the phosphate ester will result from inappropriate storage.
Sultriecin is soluble in water, optimial stability in aqueous buffered solutions at pH 6.5. NOTE: hydrolysis of the phosphate ester will result from inappropriate storage.
| References | Sultriecin, a new antifungal and antitumor antibiotic from Streptomyces roseiscleroticus. Production, isolation, structure and biological activity. Ohkuma, H. et al. J. Antibiot. 1992, 45, 1239. Fostriecin: chemistry and biology. Lewy D.S. Curr. Med. Chem. 2002, 9, 2005. |