Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin is widely used for the treatment of obesity.
Tetrahydrolipstatin is soluble in ethanol, methanol, DMF and DMSO.
Tetrahydrolipstatin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. |
| References | Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. Weibel E. et al. J. Antibiot. 1987, 40, 1081. Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin. Barbier P. et al. Helv. Chim. Acta 1987, 70, 196. The total synthesis of (−)-tetrahydrolipstatin. Bodkin J. et al. Aust. J. Chem 2003, 56, 795. |