Thalidomide is an antimalignancy cancer research compound that has shown antiangiogenic and immunomodulatory activities.
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| Mechanism of Action | The exact mechanism of thalidomide is unknown, however it has been shown to inhibit TNF-α, IL-6, IL-10 and IL-12 production while enhancing the production of IL-2, IL-4 and IL-5. It also effects natural killer cell toxicity and stimulates T lymphocytes. |
| Molecular Formula | C13H10N2O4 |
| References | Singhal, S., & Mehta, J. (2001). Thalidomide in Cancer. Biodrugs, 15(3), 163-172. http://dx.doi.org/10.1016/S0753-3322(01)00146-9 |