Ticarcillin Disodium with Clavulanate Potassium (15:1) (syn: Timentin) is a mixture of 15 parts Ticarcillin Disodium and one part Clavulanate Potassium.
Ticarcillin Disodium, is an extended-spectrum (4th generation) β-lactam in the carboxypenicillin family that acts as a cell wall synthesis inhibitor. Ticarcillin has bactericidal activity against many Gram-positive and Gram-negative bacteria, particularly Pseudomonas aeruginosa. As a β-lactam antibiotic, Ticarcillin is susceptible to β-lactamase degradation. When combined with Clavulanate Potassium, a β-lactamase inhibitor, Ticarcillin's antibacterial activity is greatly increased. Clavulanic acid is effective against organisms expressing class A β-lactamases (including CTX-M and the ESBL derivatives of TEM-1, TEM-2, and SHV-1); and are generally less effective against class B, C, and D β-lactamases.
In plant biology, Timentin is used most commonly in the regeneration medium for elimination of the Agrobacterium post-transformation of foreign DNA into plant cells. The product is freely soluble in aqueous solution.
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