Tildipirosin is a semi-synthetic antibiotic derived from a tylosin derivative by iodination and reaction with piperidine. The introduction of a third basic moiety into the tylosin core provides a wider spectrum of antibiotic action than the dibasic analogs such as tilmicosin, in particular good protection against Pasteurella. Tildipirosin's interaction with the ribosomal site of action differs from that of tylosin and tilmicosin. The compound can be used in infection models.
Tildipirosin is soluble in ethanol, methanol, DMF and DMSO.
| Molecular Formula | C41H71N3O8 |
| References |
Andersen NM et al (2012) Inhibition of protein synthesis on the ribosome by Tildipirosin compared with other veterinary macrolides. Antimicrob. Agents Chemother. 56:6033 Miyake et al. (2003) Macrolide antibiotics and treatment and prophylaxis of Pasteurellosis using the same. US Patent 6514946 Zeng, D et al (2018) Pharmacokinetics and Pharmacodynamics of Tildipirosin against Pasteurella multocida in a murine lung infection model. Front. Microbiol. 9:1038 PMID 29867911 |