SKU: T009  / 
    CAS Number: 32986-56-4

    Tobramycin

    $64.00
    Tobramycin

    Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius. Tobramycin is a member of a broad-spectrum antibiotic complex, nebramycin, that was originally isolated in 1967 by Eli Lilly and Company. The nebramycin complex was separated into various factors, with nebramycin factor 6 showing in-vitro activity of clinical usefulness. Nebramycin factor 6 was subsequently designated tobramycin.

    Tobramycin is a bactericidal protein synthesis inhibitor, able to bind to the 16S rRNA of the 30S ribosomal subunit, inhibiting translocation, and eliciting miscoding of the proteins. Tobramycin has also shown a disruptive effect on the outer membrane of Gram-negative bacteria at high concentrations.

    Tobramycin is active against Gram-negative bacteria and is frequently used to eliminate Pseudomonas aeruginosa in cystic fibrosis patients. Tobramycin, like other aminoglycosides, can be used to treat Gram-positive bacterial infection, but other types of antibiotics are more potent and less toxic. Tobramycin shows activity against mycobacteria but is mostly ineffective against fungi and viruses.

    TOKU-E offers two forms of tobramycin:

    Both forms are soluble in aqueous solution.