Fluvoxamine Maleate is a selective neuronal serotonin reuptake inhibitor with a 100-fold affinity for the serotonin transporter over the norepinephrine transporter. It is an aralkylketone-derivative agent developed by Solvay, Belgium. It inhibits many cytochrome P450 enzymes. The compound has been used in preclinical animal study models as a test compound to determine its solubility and permeability attributes. It can be used to develop an HPLC method for compound determination in the presence of its degradation products.
Fluvoxamine Maleate is sparingly soluble in water, and freely soluble in ethanol, methanol, and DMSO.
| Mechanism of Action | Fluvoxamine is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Selective serotonin reuptake inhibitors (SSRIs) increase the activity of serotonin. Its mode of action is not fully understood. |
| Molecular Formula |
C15H21F3N2O2 · C4H4O4 |
| References |
Benfield and Ward (1986) Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32 313 PMID: 3096686 Classen et al (1977) Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br.J.Pharmacol. 60 505 PMID: 302726 Foda NH, Radwan M and Deeb OA (1996) FLuvoxamine Maleate. Anal. Prof. Drug Sub. Excip. 24:165-208 Oba A et al (2013) Chronic Fluvoxamine treatment changes 5-HT(2A/2C) receptor-mediated behavior in olfactory bulbectomized mice. Life Sci. 92(2):119-124 PMID 23159642 |
