TPU-0037C (8-Dehydroxy-30-demethyllydicamycin), a close structural analogue of lydicamycin, has been shown to be highly active against MRSA. TPU-0037C is also closely related to BN 4515N which was isolated from a strain of Microtetraspora as a neuritogenic agent.
TPU-0037C is soluble in ethanol, methanol, DMF and DMSO.
TPU-0037C is soluble in ethanol, methanol, DMF and DMSO.
| Molecular Formula | C46H72N4O9 |
| References | TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598. Furumai T. et al. , J. Antibiot. 2002, 55, 873. A new neuritogenetic compound BU-4514N produced by Microtetraspora sp.. Toda S. et al. , J. Antibiot. 1993, 46, 875. Lydicamycin, a new antibiotic of a novel skeletal type. II. Physico-chemical properties and structure elucidation. Hayakawa Y. et al. , J. Antibiot. 1991, 44, 288. Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity. Hayakawa Y. et al. , J. Antibiot. 1991, 44, 282. |
