SKU: T104  / 
    CAS Number: 11089-65-9

    Tunicamycin

    3,611,539.12₫ - 12,640,386.92₫
    The tunicamycins are a family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group. The complex comprises the analogues, tunicamycins I to X. This composition is typical of other products less precisely described as tunicamycins A to D. The tunicamycins act by blocking the formation of N-glycoside linkages to proteins via inhibition of formation of dolichol monophosphate from N-acetylglucosamine-1-phosphate. Tunicamycins are broadly active against prokaryotes, eukaryotes and viruses.

    Tunicamycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    Mechanism of ActionTunicamycin blocks the synthesis of all N-linked glycoproteins (N-glycans) and causes cell cycle arrest in G1 phase.
    Molecular FormulaC38H62N4O16 (for IV)
    ReferencesRelationship of the structure and biological activity of the natural homologues of tunicamycin. Duskin D. & Mahoney W.C. J Biol Chem. 1982, 257, 3105.