Tylosin B, EvoPure® is a highly purified form of tylosin B (desmycosin). Tylosin B is a metabolite of tylosin A and forms in acidic media.
Tylosin is a macrolide antibiotic that was originally isolated from Streptomyces fradiae by the Lilly Research Laboratories in 1961 from a soil sample collected in Thailand. Tylosin is a mixture of four macrolide antibiotics of which the primary component (>80%) is Tylosin A. To a lesser degree, Tylosin B (desmycosin), Tylosin C (macrocin) and Tylosin D (relomycin) may also be present. Tylosin has broad-spectrum bacteriostatic activity against Gram-positive bacteria and mycoplasma, but much less activity against most Gram-negative bacteria and fungi.
Tylosin has been used to study protein synthesis, abscess prevention in cattle, and mycoplasma infections.
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| Application | Tylosin B, EvoPure® can be used as a reference standard and to study the individual effects of tylosin B. |
| Mechanism of Action | Tylosin, like other Macrolide antibiotics, is a bacteriostatic compound that reversibly binds to the 23S rRNA in the 50S (L27 protein) ribosome subunit and inhibits mRNA-directed protein synthesis. Tylosin B was shown not to inhibit peptidyl transferase (Poulsen et al., 2000). |
| Spectrum | Tylosin shows activity primarily against Gram-positive bacteria and species of the genus Mycoplasma. |
| References |
Loke, M. L., and F. Ingerslev. "Stability of Tylosin A in Manure Containing Test Systems Determined by High Performance Liquid Chromatography." Chemosphere 40.7 (2000): n. pag. Nih.gov. Web. 27 Dec. 2013. Thompson, T. S., S. F. Pernal, and D. K. Noot. "Degradation of Incurred Tylosin to Desmycosin--implications for Residue Analysis of Honey." Analytica Chimica 586 (2007): 304-11. Nih.gov. Web. 27 Dec. 2013. |
| MIC | Escherichia coli (B 0001)| >64|| Haemophilus influenzae (B 0529)| 4|| Pasteurella multocida| 3.13|| Staphylococcus aureus (B 0329)| 0.5|| Staphylococcus aureus (B 0330)| >64|| Staphylococcus aureus (B 0538)| 1|| Streptococcus pneumonia (B 0326)| ≤0.125|| Streptococcus pneumonia (B 0328)| >64|| Streptococcus pneumonia (B 0541)| ≤0.125|| Streptococcus pyogenes (B 0542)| ≤0.125|| Streptococcus pyogenes (B 0543)| ≤0.125|| Streptococcus pyogenes (B 0544)| >64|| |
