Valnemulin is a semi-synthetic pleuromutilin prepared by sequential reaction of pleuromutilin tosylate with 2-amino-1,1-dimethylethylthiol, coupling the free amine with a protected valine and then deprotection to provide the final product. Valnemulin is a broad spectrum antibiotic used to control gastrointestinal infections in animals and shows no cross resistance to other antibiotic classes.
Valnemulin is soluble in ethanol, methanol, DMF and DMSO.
Valnemulin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Valnemulin inhibits protein synthesis by binding to domain V of 23S RNA. |
| Molecular Formula | C31H52N2O5S |
| References | Pleuromutilin derivatives a process for their preparation and their use. Berner H. et al. 1986, US Patent 4,675,330. |
