Viridicatin is a fungal metabolite produced by several species of Penicillium and formed by the rearrangement of the benzodiazepine, cyclopenin. Viridicatin is a bioactive quinolone and alkaloid that has potent selective activity against Mycobacterium tuberculosis, but is inactive against most other bacteria.
Viridicatin is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
| Microbiology Applications |
Viridicatol is used in allergy research. In a mouse model of ovalbumin-induced food allergy it was able to alleviate allergy responses (Shu et al, 2020). |
| References |
Bracken A et al (1954) Studies in the biochemistry of microorganisms. 93. Cyclopenin, a nitrogen-containing metabolic product of Penicillium cyclopium Westling. Biochem J. 57:587 Cunningham KG and Freeman GG (1953) The isolation and some chemical properties of Viridicatin, a metabolic product of Penicillium viridicatum westling, Biochem J. 53:328-332 PMID 13032073 Shu S et al (2020) Viridicatol isolated from deep-sea Penicillium griseofulvum alleviates anaphylaxis and repairs teh intestinal barrier in mice by suppressing mast cell activation. Mar. Drugs 18(10):517 |