Viridicatumtoxin is a tetracycline-like metabolite produced by several species of Penicillium, first isolated in 1976 as a mycotoxin. Initial testing revealed that viridicatumtoxin caused myocardial deterioration, renal tubule necrosis and spleen atrophy. Analogous to the related tetracyclines, viridicatumtoxin was found to be a potent antibacterial, with activity against S. aureus including MRSA and QRSA strains. Little has been published on the mode of action of viridicatumtoxin.
Viridicatumtoxin is soluble in ethanol, methanol, DMF and DMSO.
| References | Viridicatumtoxin, a new mycotoxin from Penicillium viridicatum westling. Hutchison R.D. et al. Toxicol. Appl. Pharmacol. 1973, 24, 507. Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11. Zheng J. et al. J. Antibiot. 2008, 61, 633. |