SKU: W002  / 
    CAS Number: 105219-56-5

    WEB 2086

    R$994.56 - R$3,467.52

    WEB 2086 (apafant) is a potent and selective platelet activating (PAF) antagonist. WEB 2086 has high affinity for guinea pig peritoneal macrophage PAF receptors, dissociating slowly. WEB 2086 at 10-8 to 10-6 mol​/L strongly and concentration-​dependently inhibits PAF-​induced chemotaxis in guinea pig eosinophils. In animal models, WEB 2086 (0.1% w/v) blocks eosinophil activation in allergic conjunctivitis and inhibits the hypotensive and lethal effect of PAF in the rat in a dose-​related manner.

    Molecular Formula  C22H22ClN5O2S
    References

    Kato M et al (2004)  Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. J. Pharmacol. Sci. 95:435

    Nabe T et al (1997)  Eosinophil chemotaxis induced by several biologically active substances and the effects of apafant on it in vitro.  Arzneimittel-Forschung 47:1112

    Ring et al (1993)  Pharmacological characterization of a receptor for platelet-​activating factor on guinea pig peritoneal macrophages using [3H]​apafant, a selective and competitive platelet-​activating factor antagonist: evidence that the noncompetitive behavior of apafant in functional studies relates to slow kinetics of dissociation. Molec. Pharmacol. 43:302