Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumor and antiinflammatory activity.
Wortmannin is soluble in ethanol, methanol, DMF and DMSO.
Wortmannin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo. |
| References | The structure of wortmannin, a steroidal fungal metabolite. MacMillan J. et al. , Chem. Commun. 1968, 613. Activation of human neutrophil phospholipase D by three separable mechanisms. Reinhold S. et al. , FASEB J. 1990, 4, 208. Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil. Bonser R.W. et al. , Br. J. Pharmacol. 1991, 103, 1237. Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors. Kitani S. et al. , BBRC 1992, 183, 48. Wortmannin, a microbial product inhibitor of myosin light chain kinase. Nakanishi S. et al. , J. Biol. Chem. 1992, 267, 2157. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Arcaro A. & Wyman M.P., Biochem. J. 1993, 296, 297. |