Xanthyletin, a dimethylpyranocoumarin structurally related to psoralen, is the active principal of Luvanga scandens widely used in Hindu medicine. Xanthyletin was isolated from the New Guinea tree, Flindersia pimenteliana, by Taylor and Ritchie, University of Sydney, Australia in 1975. Xanthyletin is an inhibitor of platelet aggregation induced by arachidonic acid and collagen, and is active against L-1210 cell line in vitro.
Xanthyletin is soluble in ethanol, methanol, DMF or DMSO.
| Molecular Formula | C14H12O3 |
| References | Bowden BF (1975) The chemical constituents of Australian Flindersia species. An examination of F. pimenteliana. Aust. J. Chem. 28:1393 Dall'Acqua F et al (1979) Photochemical interaction between xanthyletine and DNA. Photochem. Photobiol. 2:283 Khan AJ et al (1985) Structure and biological activity of xanthyletin a new phytoalexin of citrus. Fruits 40:807 Magiatis P. et al (1998) Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series. J. Nat. Prod. 61:982 Teng CM et al. (1992) Antiplatelet actions of some coumarin compounds isolated from plant sources. , Thromb. Res. 66:549
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