Cefmetazole is a broad spectrum second generation cephalosporin antibiotic. TOKU-E offers two forms of cefmetazole: cefmetazole, free acid (C122), and cefmetazole sodium (C052). Cefmetazole is freely soluble in water 92 mg/mL.
| Mechanism of Action | Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. |
| Spectrum | Cefmetazole is broad spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria. Cefmetazole is more potent against many Gram-negative enteric flora and pathogens than other first generation cephalosporins. |
| Microbiology Applications | Cefmetazole is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive and Gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
For a complete list of cefmetazole MIC values, click here. |
| Molecular Formula | C15H16N7O5S3Na |
| References | Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012. |
| MIC | Bacteroides caccae| 32 － >18| 1475| Bacteroides distasonis| 16 － >128| 1477| Bacteroides distasonis (ATCC 8503)| 2 － ?| 1477| Bacteroides eggerthii (ATCC 27754)| 4 － ?| 1477| Bacteroides fragilis| 4 － 32| 1475| Bacteroides fragilis| 8 － 32| 1477| Bacteroides fragilis (1995)| 2 － >256| 297| Bacteroides fragilis (1996)| 2 － >256| 297| Bacteroides fragilis (ATCC 25285)| 8 － ?| 1477| Bacteroides fragilis (GAI 0558)| 8 － ?| 1477| Bacteroides fragilis (GAI 10150)| 64 － ?| 1477| Bacteroides fragilis (GAI 5562)| 8 － ?| 1477| Bacteroides fragilis (GAI 7955)| 128 － ?| 1477| Bacteroides fragilis (group)| 0.06 － >=256| 1480| Bacteroides fragilis (group)| 4 － >128| 1399| Bacteroides fragilis (group)| 0.12 － >128| 1475| Bacteroides fragilis (Imipenem-resistant)| 16 － >128| 1477| Bacteroides fragilis (NCTC 10581)| 8 － ?| 1477| Bacteroides ovatus (ATCC 8483)| 128 － ?| 1477| Bacteroides thetaiotaomicron| 8 － >128| 1475| Bacteroides thetaiotaomicron| 64 － 128| 1477| Bacteroides thetaiotaomicron (ATCC 29741)| 64 － ?| 1477| Bacteroides thetaiotaomicron (Imipenem-resistant)| 16 － >128| 1477| Bacteroides uniformis| 32 － >128| 1475| Bacteroides uniformis (ATCC 8492)| 2 － ?| 1477| Bacteroides ureolyticus (NCTC 10941)| 0.25 － ?| 1477| Bacteroides vulgatus| 0.12 － >128| 1475| Bacteroides vulgatus (ATCC 8482)| 2 － ?| 1477| Bifidobacterium adolescentis (ATCC 15703)| 0.25 － ?| 1477| Bifidobacterium bifidum (JCM 1255)| 0.25 － ?| 1477| Bifidobacterium breve (ATCC 15700)| 4 － ?| 1477| Bifidobacterium longum (ATCC 15707)| 4 － ?| 1477| Bifidobacterium pseudolongum (ATCC 25526)| 0.5 － ?| 1477| Bilophila wadsworthia (WAL 7959)| 8 － ?| 1477| Campylobacter gracilis (JCM 8538)| 8 － ?| 1477| Capnocytophaga ochracea (GAI 5586)| 2 － ?| 1477| Clostridium bifermentans (NCTC 06800)| 0.25 － ?| 1477| Clostridium butyricum| 0.06 － 32| 1475| Clostridium clostridioforme| 0.06 － 32| 1475| Clostridium clostridioforme (NCTC 11224)| 16 － ?| 1477| Clostridium difficile| 8 － >128| 1477| Clostridium difficile (GAI 10029)| 32 － ?| 1477| Clostridium paraputrificum (ATCC 25780)| 0.5 － ?| 1477| Clostridium perfringens| <=0.03 － 0.25| 1475| Clostridium perfringens| 0.06 － 0.5| 1477| Clostridium perfringens (ATCC 13124)| 0.125 － ?| 1477| Clostridium putrificum (ATCC 25784)| 0.25 － ?| 1477| Clostridium ramosum| 0.06 － 32| 1475| Clostridium ramosum (ATCC 25582)| 4 － ?| 1477| Clostridium septicum| 0.06 － 32| 1475| Clostridium septicum (ATCC 12464)| 0.125 － ?| 1477| Clostridium sordellii (NCTC 06929)| 0.25 － ?| 1477| Clostridium sordellii (NCTC 08780)| 0.5 － ?| 1477| Clostridium sporogenes| 0.06 － 32| 1475| Clostridium spp.| <=0.03 － 0.5| 1477| Desulfovibrio piger (DSM 749)| 16 － ?| 1477| Eggerthella lenta (ATCC 25559)| 16 － ?| 1477| Eggerthella lenta (ATCC 43055)| 16 － ?| 1477| Finegoldia magna (ATCC 29328)| 1 － ?| 1477| Finegoldia magna (Levofloxacin-resistant)| 0.125 － 2| 1477| Fusobacterium (penicillin-susceptible)| ≤0.015 － 16| 1396| Fusobacterium (penicillin-susceptible)| 0.5 － 8| 1396| Fusobacterium mortiferum| <=0.03 － 32| 1475| Fusobacterium necrophorum| 0.06 － 16| 1477| Fusobacterium necrophorum| <=0.03 － 32| 1475| Fusobacterium necrophorum (ATCC 25286)| 0.06 － ?| 1477| Fusobacterium nucleatum| 0.06 － 16| 1477| Fusobacterium nucleatum| <=0.03 － 32| 1475| Fusobacterium nucleatum (ATCC 25586)| 1 － ?| 1477| Fusobacterium spp.| 0.06 － 16| 1477| Fusobacterium spp.| <=0.03 － 32| 1475| Fusobacterium varium| <=0.03 － 32| 1475| Fusobacterium varium (ATCC 8501)| 4 － ?| 1477| Gemella morbillorum (ATCC 27824)| 0.25 － ?| 1477| Klebsiella pneumonia (ESBL)| ? － ?| 1298| Lactobacillus acidophilus (JCM 1132)| 8 － ?| 1477| Lactobacillus brevis (JCM 1059)| 64 － ?| 1477| Lactobacillus casei (JCM 1134)| 128 － ?| 1477| Lactobacillus fermentum (JCM 1173)| 128 － ?| 1477| Lactobacillus plantarum (JCM 1149)| >128 － ?| 1477| Lactobacillus reuteri (JCM 1112)| >128 － ?| 1477| Lactobacillus salivarius (JCM 1231)| 32 － ?| 1477| Micromonas micros| 0.25 － 16| 1477| Micromonas micros (VPI 5464-1)| 0.25 － ?| 1477| Pasteurella multocida| <4 － ?| 1092| Peptoniphilus asaccharolyticus (Levofloxacin-resistant)| 0.125 － 2| 1477| Peptoniphilus asaccharolyticus (WAL 3218)| 0.25 － ?| 1477| Peptoniphilus indolicus (GAI 0915)| 0.06 － ?| 1477| Peptostreptococcus (penicillin-resistant)| ≤0.015 － 16| 1396| Peptostreptococcus (penicillin-susceptible)| ≤0.015 － 4| 1396| Peptostreptococcus anaerobius| <=0.03 － 128| 1475| Peptostreptococcus anaerobius (ATCC 27337)| 0.5 － ?| 1477| Peptostreptococcus anaerobius (Levofloxacin-resistant)| 0.125 － 2| 1477| Peptostreptococcus magnus| <=0.03 － 128| 1475| Peptostreptococcus micros| <=0.03 － 128| 1475| Peptostreptococcus spp.| <=0.03 － 128| 1475| Porphyromonas (penicillin-susceptible)| ≤0.015 － 1| 1396| Porphyromonas asaccharolytica (ATCC 25260)| 0.125 － ?| 1477| Porphyromonas gingivalis (ATCC 33277)| 0.06 － ?| 1477| Prevotella bivia (ATCC 29303)| 8 － ?| 1477| Prevotella buccae| 0.12 － >128| 1475| Prevotella buccae (ATCC 33574)| 2 － ?| 1477| Prevotella corporis (GAI 91000)| 0.5 － ?| 1477| Prevotella heparinolytica (ATCC 35895)| 0.5 － ?| 1477| Prevotella intermedia| 0.12 － >128| 1475| Prevotella intermedia (ATCC 25611)| 0.25 － ?| 1477| Prevotella melaninogenica| 0.06 － 16| 1477| Prevotella melaninogenica (GAI 5490)| 0.25 － ?| 1477| Prevotella melaninogenicus| 0.12 － >128| 1475| Prevotella oralis| 0.12 － >128| 1475| Prevotella oralis (ATCC 33269)| 2 － ?| 1477| Prevotella oris (ATCC 33573)| 1 － ?| 1477| Prevotella spp.| 0.06 － 16| 1477| Prevotella spp.| 0.06 － 16| 1477| Prevotella spp.| 0.12 － >128| 1475| Propionibacterium acnes | 0.06 - 0.25| 1477| Propionibacterium acnes (ATCC 11828)| 1 － ?| 1477| Propionibacterium granulosum (ATCC 25564)| 2 － ?| 1477| Staphylococcus aureus (352 + methicillin-resistant)| 8 － ?| 1398| Staphylococcus aureus (3818 + methicillin-resistant)| 8 － ?| 1398| Staphylococcus aureus (4952 + methicillin-resistant)| 8 － ?| 1398| Staphylococcus aureus (5914 + methicillin-resistant)| >16 － ?| 1398| Staphylococcus aureus (6849 + methicillin-resistant)| 16 － ?| 1398| Staphylococcus aureus (ATCC 29213 + methicillin-susceptible)| 1 － ?| 1398| Staphylococcus aureus (FDA 209P)| 0.5 － ?| 349| Staphylococcus aureus (MU3)| 256 － ?| 349| Staphylococcus saccharolyticus (ATCC 14953)| 0.5 － ?| 1477| Streptococci (Viridans group + penicillin-susceptible)| ≤0.015 － 8| 1396| Streptococcus constellatus (ATCC 27923)| 2 － ?| 1477| Streptococcus intermedius (ATCC 27335)| 2 － ?| 1477| Sutterella wadsworthensis (ATCC 51579)| 8 － ?| 1477| Veillonella dispar (ATCC 17748)| 0.25 － ?| 1477| Veillonella parvula| <=0.03 - 32| 1475| Veillonella parvula(ATCC 10790)| 0.25 － ?| 1477| Veillonella spp.| <=0.03 － 32| 1475| |
