SKU: P067  / 
    CAS Number: 18851-33-7

    1,10-Phenanthroline Hydrochloride Monohydrate

    $58.00 - $209.50
    • Detailed Description

      CAS Number: 18851-33-7

      Molecular Formula:

      C12H8N2 · HCl · H2O

      Molecular Weight: 234.68

      Mechanism of Action: 1,10-Phenanthroline Hydrochloride Monohydrate damages mitochondrial function in fungi by disabling the ability to reduce 2,3,5-triphenyltetrazolium chloride (TTC). 1,10-Phenanthroline also inhibits DNA synthesis in cancer cells; however, the mechanism is poorly understood.

      Storage Conditions: ≤30°C

    • Applications

      Cancer Applications: Chemotherapeutic potential of 1,10-Phenanthroline and three of its transition metal complexes was determined using two human carcinoma cell lines (A-498 and Hep-G2).  The compound induced a concentration-dependent cytotoxic effect, with metal complexes demonstrating the greatest cytotoxic response  (Deegan et al, 2007).

    • Specifications

      Appearance: White to off-white powder

      Water Content (Karl Fischer): Not more than 8.5%

      Identification: IR - Passes test

      Purity Level: (Titration) 99.0% - 101.0%

    • References

      References:

      Coyle B (2003)  Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. BioMetals 16: 321-329 PMID 12572690

      Deegan C et al  (2007)  In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)] · 2H2O, [Cu(phen)2(mal)] · 2H2O and [Mn(phen)2(mal)] · 2H2O (malH2 = Malonic Acid) Using Human Cancer Cells. Cancer Lett.  247(2):224-233 

    1,10-Phenanthroline Hydrochloride Monohydrate is a heterocyclic compound with antimycotic and anticancer properties.  It is used as an analytical reagent for colorimetric determination of iron.  The compound an inhibit metallopeptidases, primarily zinc.  Phenathronline can be used in titrations to detect alkyllithium reagents.  The product is soluble in water.
      
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    CAS Number: 18851-33-7

    Molecular Formula:

    C12H8N2 · HCl · H2O

    Molecular Weight: 234.68

    Mechanism of Action: 1,10-Phenanthroline Hydrochloride Monohydrate damages mitochondrial function in fungi by disabling the ability to reduce 2,3,5-triphenyltetrazolium chloride (TTC). 1,10-Phenanthroline also inhibits DNA synthesis in cancer cells; however, the mechanism is poorly understood.

    Storage Conditions: ≤30°C

    Cancer Applications: Chemotherapeutic potential of 1,10-Phenanthroline and three of its transition metal complexes was determined using two human carcinoma cell lines (A-498 and Hep-G2).  The compound induced a concentration-dependent cytotoxic effect, with metal complexes demonstrating the greatest cytotoxic response  (Deegan et al, 2007).

    Appearance: White to off-white powder

    Water Content (Karl Fischer): Not more than 8.5%

    Identification: IR - Passes test

    Purity Level: (Titration) 99.0% - 101.0%

    References:

    Coyle B (2003)  Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. BioMetals 16: 321-329 PMID 12572690

    Deegan C et al  (2007)  In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)] · 2H2O, [Cu(phen)2(mal)] · 2H2O and [Mn(phen)2(mal)] · 2H2O (malH2 = Malonic Acid) Using Human Cancer Cells. Cancer Lett.  247(2):224-233