SKU: N046  / 
    CAS Number: 7177-50-6

    Nafcillin sodium salt monohydrate

    Nafcillin is a beta-lactamase-resistant drug of the penicillin class.
    Mechanism of Actionβ-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
    SpectrumNafcillin is targets primarily gram-positive bacteria including Staphylococcus and Streptococcus species.
    Molecular FormulaC21H21N2O5SNa•H2O
    ReferencesGuzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.