1,10-Phenanthroline Hydrochloride Monohydrate is a herterocyclic compound with antimycotic and anticancer properties.
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|Mechanism of Action||1,10-Phenanthroline Hydrochloride Monohydrate damages mitochondrial function in fungi by disabling the ability to reduce 2,3,5-triphenyltetrazolium chloride (TTC). 1,10-Phenanthroline also inhibits DNA synthesis in cancer cells; however, the mechanism is poorly understood.|
C12H8N2 · HCl · H2O
|Cancer Applications||Chemotherapeutic potential of 1,10-Phenanthroline and three of its transition metal complexes was determined using two human carcinoma cell lines (A-498 and Hep-G2). The compound induced a concentration-dependent cytotoxic effect, with metal complexes demonstrating the greatest cytotoxic response (Deegan et al, 2007).|
Coyle B (2003) Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. BioMetals 16: 321-329 PMID 12572690
Deegan C et al (2007) In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)] · 2H2O, [Cu(phen)2(mal)] · 2H2O and [Mn(phen)2(mal)] · 2H2O (malH2 = Malonic Acid) Using Human Cancer Cells. Cancer Lett. 247(2):224-233