1-Alaninechlamydocin is a cyclic tetrapeptide metabolite containing a single β-amino acid, which was isolated from a Tolypocladium sp. from the Great Lakes. It has anti-tumor activity due to the inhibition of histone deacetylase (HDAC).
1-Alaninechlamydocin is soluble in ethanol, methanol, DMF and DMSO.
|Mechanism of Action||1-Alaninechlamydocin exhibits potent antitumor activity and acts by inhibiting histone deacetylase.|
|Eukaryotic Cell Culture Applications|| |
1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
|Cancer Applications|| |
1-Alaninechlamydocin showed antiproliferative/cytotoxic activity in human pancreatic cancer cell line (MIA PaCa-2) at low-nanomolar concentrations. It also induced G2/M cell cycle arrest and apoptosis. Similar to other cyclic epoxytetrapeptides, its inhibitory effect is proposed to be via inhibition of HDAC activity (Du et al, 2014).
Du L, Risinger AL, King JB, Powell DR and Cichewicz RH (2014) A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J. Nat. Prod. 77(7):1753-1757
Kim SD et al (1992) Han'guk Saenghwa Hakhoechi 25:5