1-Alaninechlamydocin is a cyclic tetrapeptide metabolite containing a single β-amino acid, which was isolated from a Tolypocladium sp. from the Great Lakes. It has anti-cancer properties due to the inhibition of histone deacetylase (HDAC).
1-Alaninechlamydocin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action |
1-Alaninechlamydocin exhibits potent antitumor activity and acts by inhibiting histone deacetylase. |
| Eukaryotic Cell Culture Applications | 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively). |
| Cancer Applications | 1-Alaninechlamydocin showed antiproliferative/cytotoxic activity in human pancreatic cancer cell line (MIA PaCa-2) at low-nanomolar concentrations. It also induced G2/M cell cycle arrest and apoptosis. Similar to other cyclic epoxytetrapeptides, its inhibitory effect is proposed to be via inhibition of HDAC activity (Du et al, 2014). |
| Molecular Formula | C27H36N4O6 |
| References |
Du L, Risinger AL, King JB, Powell DR and Cichewicz RH (2014) A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J. Nat. Prod. 77(7):1753-1757 Kim SD et al (1992) Han'guk Saenghwa Hakhoechi 25:5 |
