SKU: U007  / 
    CAS Number: 151271-53-3

    UK-1

    $266.16 - $931.59
    UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumor activity but is devoid of antimicrobial activity.
    Mechanism of ActionUK-1 acts as a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II.
    Molecular FormulaC22H14N2O5
    ReferencesUK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physicochemical and biological properties. Ueki M. et al. J. Antibiot. 1993, 46, 1089. 

    UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II Structure elucidation. Shibata K. J. Antibiot. 1993, 46, 1095. 

    The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II. Reynolds M. B. et al. Bioorg. Chem. 1999, 27, 326.