SKU: D041  / 
    CAS Number: 110415-68-4

    Delta-2-Avermectin B1a

    $266.55 - $932.92

    Delta-2-Avermectin B1a is a natural,  irreversible base degradation product produced by selective hydrolysis of the terminal saccharide Avermectin under acidic conditions in animals and in the environment.  Delta-2-Avermectin B1a is formed by rearrangement of the naturally-occurring delta-3-group to the 2-position. Although less active than the parent, Delta-2-Avermectin B1a is nonetheless active at 1 ppm.  Avermectins are a family of natural macrocyclic lactones produced by the soil actinomycete Streptomyces avermitilis. There are eight different Avermectin natural product compounds: A1a, A1b, A2a, A2b, B1a, B1b, B2a, and B2b based upon the structure of the individual compounds.  The B1 fraction has the most effective antiparasitic activity.

    Delta-2-Avermectin B1a is soluble in ethanol, methanol, DMF and DMSO.  

    Mechanism of Action Avermectins can modulate gamma-aminobutyric acid (GABA) chloride channels in vertebrate neurons.  
    Insect Biology Applications Electrophysiological findings by injection of E. elegans mRNA into Xenopus laevis oocytes indicated that Avermectins act on glutamate-gated chloride channels in nematodes.

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    Egerton JR et al (year)  Avermectins, new family of potent anthelmintic agents: Efficacy of the B1a component. Antimicrob. Agents Chemother. 15(3):372-378  PMID 464563

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    Pivnichny JV, Shim JK and Zimmerman LA (1983)  Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. J. Pharm. Sci. 72(12):1447-1450  PMID 464563