SKU: A194  / 
    CAS Number: 50722-38-8

    3-Acetyldeoxynivalenol

    $186.50 - $651.50
    3-Acetyldeoxynivalenol
    • Detailed Description

      CAS Number: 50722-38-8

      Molecular Formula: C17H22O7

      Molecular Weight: 338.4

      Tariff Code: 3822.00.5090

    • Specifications

      Form: Solid

      Appearance: White crystalline solid

      Source: Fusarium graminearum

    • Technical Data

      Solubility: Soluble in methanol or DMSO

    • References

      References:

      Atkinson HA and Miller K (1984)  Inhibitory effect of deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone on induction of rat and human lymphocyte proliferation. Toxicol. Lett. 23:215

      Kadota T et al (1888)  Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol. In Vitro 27:1888

      Liu N et al.  3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages. Environ. Pollut. 265 (Pt B):114697

    3-Acetyldeoxynivalenol is a trichothecene mycotoxin produced by Fusarium species, exhibiting dose-dependent reduction of lymphocyte proliferation in mitogen-induced blastogenesis, albeit less potently than deoxynivalenol. In a comparative study of deoxynivalenol and its 3- and 15-acetyl derivatives on transepithelial transport, gene expression, and cytokine secretion in human intestinal cell Caco-2, all metabolites could induce mRNA expression and production of IL-8, with 3-acetyldeoxynivalenol being less potent than it 15-acetyl analogue. 3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.

     

    CAS Number: 50722-38-8

    Molecular Formula: C17H22O7

    Molecular Weight: 338.4

    Tariff Code: 3822.00.5090

    Form: Solid

    Appearance: White crystalline solid

    Source: Fusarium graminearum

    Solubility: Soluble in methanol or DMSO

    References:

    Atkinson HA and Miller K (1984)  Inhibitory effect of deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone on induction of rat and human lymphocyte proliferation. Toxicol. Lett. 23:215

    Kadota T et al (1888)  Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol. In Vitro 27:1888

    Liu N et al.  3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages. Environ. Pollut. 265 (Pt B):114697